Uveitis Diagnosis by Subtype

Anterior Uveitis

Mimics: leukemia, lymphoma, RBCs, pigment dispersion, foreign body

Granulomatous:Non-Granulomatous:
SarcoidosisHLA B27
TBHerpes Group (esp unilateral)
Herpes groupTINU (esp acute/bilateral)
ToxoplasmosisFuch’s Uveitis (heterochromia)
SO/VKHJIA
Blau Syndrome (child)Spirochetes (Syphilis, Lyme)
Bactrim etcBehcet 
Moxifloxacin (iris transillumination)Post-infectious/reactive 
Spirochetes (Syphilis, Lyme)Other: Posner Schlossman or drug-related
MS associated uveitis 
Lens induced 

Intermediate uveitis 

(Primary vitreous involvement +/-retinal vascular sheathing, CME, disc edema)

Infectious:       Non-Infectious:
SyphilisMultiple Sclerosis
TBSarcoidosis
Lyme DiseaseInflammatory bowel dz (Crohns, UC)
Bartonellosis (cat scratch) 
Toxocara (unilateral) 
HTLV-1 (joint/CNS findings) 
Whipple’s Disease (bowel and neuro dz) 
?Toxoplasmosis 

Retinitis (chorioretinitis)

(Mimics: lymphoma, leukemia, met carcinoma, focal ischemia) Rule Out Infection!

Note: multimodal imaging is especially helpful in white dot syndromes

Infectious:    Non-Infectious:
Toxoplasmosis (most common focal)White dot syndromes (e.g. APMPPE)
Herpes group (HSV/VZV/CMV)Acute macular neuroretinitis (AMN)
SyphilisBehcet Disease
Bartonella (cat scratch) 
DUSN 
Toxocara 
Lyme Disease 
Endogenous fungus or bacteria 
Emerging (Dengue, Yellow fever, West Nile) 

Choroiditis:

(mimics: benign and malignant tumors, Leukemic/lymphoproliferative infiltrates, scleritis)

Infectious:Non-Infectious:
SyphilisSarcoidosis
Lyme DiseaseAPMMPE
TB (including Serpiginous-like)Multifocal Choroiditis (+/- panuveitis)
Endogenous fungal/bacterialPunctate Inner Choroiditis (PIC)
Cryptococcus (rare)Ocular Histoplasmosis Syndrome
Coccidiodomycosis (rare)Birdshot Choroiditis
Emerging dz (West Nile Virus)Serpiginous and Relentless Placoid 
 Blau Syndrome (AD, sarcoid-like)

Panuveitis:

Infectious:Non-Infectious:
SyphilisSarcoidosis
TBMultifocal Choroiditis with Panuveitis
ToxoplasmosisVKH
ARN/PORNSympathetic Ophthalmia
Endogenous fungal/bacterial 
Lyme Disease 
Onchocerciasis (outside US) 

Retinal Vasculitis:

Infectious:Non-Infectious:
SyphilisSarcoidosis
Herpes group (Frosted branch)Eales Disease (?TB)
para-viral syndromeSLE, PAN, Churg Strauss, Wegener
HIVBirdshot (before choroiditis)
ToxoplasmosisMultiple Sclerosis
 Behcet Disease
Primary Artery:Primary Vein:Arteries and Veins:
SyphilisSarcoidosisMS
Herpes GroupEales DiseaseBehcet Disease
SLE, PAN, Churg Strausspara-viral syndromesWegener
Frosted Branch AngiitisHIVFrosted Branch Angiitis
 Toxoplasmosis 
 Birdshot (before choroiditis) 

By Scott E. Pautler, MD

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